Pentose Phosphate Pathway

-This pathway produces ribose, forms glucose, and it also generates NADPH.

-Two Major Phases:

1.Oxidative Phase:-Generates NADPH

2.Non-oxidative Phase:-

Involves the synthesis of ribose and other sugar .

Oxidative Phase: (Glucose 6-P→ Ribose-5-P)

Glucose 6-phosphate dehydrogenase:-

First enzymatic step in the oxidative phase, converting NADP+ to NADPH.

Glucose 6-phosphate → 6-phosphogluconate + H2O

Lactonase:-

⭐Glucose 6-phosphate substrate is in the pyranose (hemiacetal) ring form with the carbon-5 oxygen linked to carbon-1, the initial product is an internal ester, 6-phosphoglucono δ-lactone, that is then cleaved by lactonase to yield 6-phosphogluconate.

Glucose-6-phosphate dehydrogenase:-

This enzyme helps protect red blood cells from damage and premature destruction.

Glucose-6-phosphate dehydrogenase is responsible for the first step in the pentose phosphate pathway, a series of chemical reactions that convert glucose (a type of sugar found in most carbohydrates) to another sugar, ribose-5-phosphate.

Non-Oxidative Phase

Converts ribulose 5-phosphate to glucose 6-phosphate.Involves multiple enzyme-catalyzed steps.

Regulation of Pentose Phosphate Pathway

NADPH which is generated in the oxidative branch pathway to feed back and inhibit the pathway Glucose 6-phosphate can still be utilized by glycolysis.

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